leukocyte rolling การใช้

• This increases the initial leukocyte rolling speed, prolonging the slow rolling phase.
• Sulf1 and 2 also display regulation over muscle development, angiogenesis, leukocyte rolling and wound healing.
• Selectins, a group of proteins that are involved in leukocyte rolling towards a source of inflammation, contain an EGF-like domain along with a lectin domain and short consensus repeats ( SCRs ).
• In leukocyte rolling, the  open conformation of the selectin allows it to bind to inward sialyl Lewis molecules farther up along the PSGL-1 chain, increasing overall binding affinity if the selectin-sialyl Lewis bond breaks, it can slide and form new bonds with the other sialyl Lewis molecules down the chain.